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Article

Research progress and application prospects of multi-omics integration strategies in precision risk stratification of type 1 diabetes mellitus.

Frontiers in immunology - 1 Jan 2026

Chen Ziyi, Liu Wentao, Guo Zheng, Guo Yuying, Hou Jiaxin, Rong Mengpeng, Zheng Huijuan, Cui Zhaoli

Abstract excerpt

Type 1 diabetes (T1D) is a chronic metabolic disease mediated by autoimmunity. Its pathogenesis involves complex interactions between genetic susceptibility and environmental factors. Conventional T1D risk stratification primarily relies on genetic markers, islet autoantibodies, and glycemic indicators. Although these biomarkers remain indispensable in current clinical practice, they are often insufficient when...

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Topics

Humans
Diabetes Mellitus, Type 1
Multiomics
Biomarkers
Risk Assessment
Precision Medicine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Metabolomics

Genomics

Genetic Predisposition to Disease

Proteomics

Animals

Source

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Identifiers

PMID: 42688815
DOI: 10.3389/fimmu.2026.1891938
PMCID: PMC13535663

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