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Article

Investigating Bidirectional Causal Relationships Between Imaging-Derived Brain Phenotypes and Sedative-Hypnotic Use Disorder: A Mendelian Randomization Study.

Addiction biology - 1 Jun 2026

Lu Liqin, Zhuang Guoxin, Deng Jue, Huang Siheng, Meng Liang, Li Fenglan, Zhu Xiaoli

Abstract excerpt

Despite sedative-hypnotic use disorder (SHUD) being a major public health priority due to its high abuse liability, the underlying causal neurobiological mechanisms of individual susceptibility remain largely unknown. We conducted a large-scale, bidirectional two-sample Mendelian randomization (MR) study utilizing genome-wide association study (GWAS) summary statistics for 3935 brain imaging-derived phenotypes...

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Identifiers

PMID: 42209116
DOI: 10.1111/adb.70160
PMCID: PMC13239158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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