Article
Engineering vascular tissue with functional smooth muscle cells derived from human iPS cells and nanofibrous scaffolds.
Biomaterials - 1 Oct 2014
Wang Yongyu, Hu Jiang, Jiao Jiao, Liu Zhongning, Zhou Zhou, Zhao Chao, Chang Lung-Ji, Chen Y Eugene, Ma Peter X, Yang Bo
Abstract excerpt
Tissue-engineered blood vessels (TEBVs) are promising in the replacement of diseased vascular tissues. However, it remains a great challenge to obtain a sufficient number of functional smooth muscle cells (SMCs) in a clinical setting to construct patient-specific TEBVs. In addition, it is critical to develop a scaffold to accommodate these cells and retain their functional phenotype for the regeneration of TEBVs....
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