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Article

Autistic-relevant behavioral phenotypes of a mouse model of cyclin-dependent kinase-like 5 deficiency disorder.

Autism research : official journal of the International Society for Autism Research - 1 Sept 2024

Mottolese Nicola, Coiffard Oceane, Ferraguto Celeste, Manolis Athanasios, Ciani Elisabetta, Pietropaolo Susanna

Abstract excerpt

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene and characterized by early-onset epilepsy, intellectual disability, and autistic features. To date, the etiological mechanisms underlying CDD are largely unknown and no effective therapies are available. The Cdkl5 knock-out (KO) mouse has been broadly employed in...

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Identifiers

PMID: 39234879
DOI: 10.1002/aur.3226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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