Article
The ASD Living Biology: from cell proliferation to clinical phenotype.
Molecular psychiatry - 1 Jan 2019
Courchesne Eric, Pramparo Tiziano, Gazestani Vahid H, Lombardo Michael V, Pierce Karen, Lewis Nathan E
Abstract excerpt
Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the lay public because of its uncertain origins and striking and unexplained clinical heterogeneity. Here we review genetic, genomic, cellular, postmortem, animal model, and cell model evidence that shows ASD begins in the womb. This evidence leads to a new theory that ASD is a multistage, progressive disorder of brain...
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