Article
Unraveling the genetics of transformed splenic marginal zone lymphoma.
Blood advances - 25 Jul 2023
Grau Marta, López Cristina, Navarro Alba, Frigola Gerard, Nadeu Ferran, Clot Guillem, Bastidas-Mora Gabriela, Alcoceba Miguel, Baptista Maria Joao, Blanes Margarita, Colomer Dolors, Costa Dolors, Domingo-Domènech Eva, Enjuanes Anna, Escoda Lourdes, Forcada Pilar, Giné Eva, Lopez-Guerra Mónica, Ramón Olga, Rivas-Delgado Alfredo, Vicente Folch Laura, Wotherspoon Andrew, Climent Fina, Campo Elias, López-Guillermo Armando, Matutes Estella, Beà Sílvia
Abstract excerpt
The genetic mechanisms associated with splenic marginal zone lymphoma (SMZL) transformation are not well defined. We studied 41 patients with SMZL that eventually underwent large B-cell lymphoma transformation. Tumor material was obtained either only at diagnosis (9 patients), at diagnosis and transformation (18 patients), and only at transformation (14 patients). Samples were categorized in 2 groups: (1) at...
Topics
- Humans
- Splenic Neoplasms
- Mutation
- Translocation, Genetic
- Lymphoma, Large B-Cell, Diffuse
- Leukemia, Lymphocytic, Chronic, B-Cell