Article
Insulin Receptor-Related Receptor Activation by Artificial Double-ER Mutations in the Transmembrane Domain.
International journal of molecular sciences - 14 May 2026
Serova Oxana V, Gavrilenkova Alina A, Kuznetsov Andrey S, Goryashchenko Alexander S, Agisheva Alexandra R, Bershatsky Yaroslav V, Lushpa Vladislav A, Zangieva Olga T, Karbyshev Mikhail S, Gerasimov Andrei S, Okhrimenko Ivan S, Efremov Roman G, Deyev Igor E, Bocharov Eduard V
Abstract excerpt
The orphan insulin receptor-related receptor (IRR), in contrast to its homologs from the insulin receptor family, is activated by a mildly alkaline extracellular medium. We have previously demonstrated that IRR activation is defined by two synergistic sites located in the dimeric extracellular domain. Here, we describe artificial mutations in the IRR transmembrane domain that promote receptor activation. First,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.