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Article

Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1.

Biochemical pharmacology - 1 Oct 2018

Furness S G B, Christopoulos A, Sexton P M, Wootten D

Abstract excerpt

The glucagon-like peptide 1 receptor (GLP-1R) can be activated by a number of endogenous peptide hormones, including extended, processed, glycine extended and carboxy-terminally amidated versions of glucagon-like peptide 1 (GLP-1). While the main focus of the literature has been on the processed, amidated form, GLP-1(7-36)NH2, the other forms of this peptide are likely to be secreted in physiologically relevant...

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PMID: 30149018
DOI: 10.1016/j.bcp.2018.08.033

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