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Article

Somatic Mutation Trajectories Define Prognostically Distinct Subtypes and Shape the Tumor Microenvironment in Gastric Cancer.

Genes - 30 Apr 2026

Shen Yikang, Pang Huaxin, Liu Haiyu, Ma Pengzhen, Liu Mingrui, Li Yaning, Wang Qihao, Xie Xiaoxia, Zhang Xiaoping, Zhao Yufeng

Abstract excerpt

Objective: Gastric cancer (GC) is characterized by molecular heterogeneity, yet current classifications are largely based on cross-sectional molecular profiles and do not account for the temporal order of mutation accumulation. This study aimed to reconstruct somatic mutation trajectories to identify prognostically distinct subtypes and to examine transcriptomic and microenvironmental features associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42194993
DOI: 10.3390/genes17050536
PMCID: PMC13205182

Genes

TP53
SCN4A
SDHD
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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