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Article

Differential genetic mutations and immune cell infiltration in high- and low-risk STAD: Implications for prognosis and immunotherapy efficacy.

Journal of cellular and molecular medicine - 1 Apr 2024

Deng Yin-Yong, Sun Yan, Wu Si-Jia, Zhang Tian-Ying, Yang Jie, Liu Kai

Abstract excerpt

This study investigates genetic mutations and immune cell dynamics in stomach adenocarcinoma (STAD), focusing on identifying prognostic markers and therapeutic targets. Analysis of TCGA-STAD samples revealed C > A as the most common single nucleotide variant (SNV) in both high and low-risk groups. Key mutated driver genes included TTN, TP53 and MUC16, with frame-shift mutations more prevalent in the low-risk...

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Identifiers

PMID: 38494839
DOI: 10.1111/jcmm.18174
PMCID: PMC10945082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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