Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathway Mutation Accumulate Perturbation Score: A prognostic and predictive biomarker for immunotherapy in advanced gastric cancer.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Apr 2026

Zhang Ziyan, Yang Guihua, Xing Yuming, Gao Yunfei, Lu Huaimin

Abstract excerpt

BACKGROUND: Gastric cancer (GC) remains highly lethal, with limited available biomarkers. The Pathway Mutation Accumulation Perturbation Score (PMAPscore), which leverages pathway-level mutations, provides a novel approach to predicting immunotherapy response and survival outcomes. OBJECTIVES: To evaluate the prognostic and predictive value of the PMAPscore in patients with advanced GC undergoing immunotherapy....

Topics

Join the communities discussing this publication.

Aged
Biomarkers, Tumor
GC gene
Immunotherapy
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Stomach Neoplasms

Source

Identifiers

PMID: 41837463
DOI: 10.17219/acem/206937

Genes

GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathway Mutation Accumulate Perturbation Score: A prognostic and predictive biomarker for immunotherapy in advanced gastric cancer.PMID 41837463Read ↗

TM-Score predicts immunotherapy efficacy and improves the performance of the machine learning prognostic model in gastric cancer.Semantic proximity Read ↗

Comprehensive analysis of tumor mutation burden and immune microenvironment in gastric cancer.Semantic proximity Read ↗

Characterization of Tumor Mutation Burden-Based Gene Signature and Molecular Subtypes to Assist Precision Treatment in Gastric Cancer.Semantic proximity Read ↗

Identification of a Gene Prognostic Model of Gastric Cancer Based on Analysis of Tumor Mutation Burden.Semantic proximity Read ↗

Significance of Tumor Mutation Burden Combined With Immune Infiltrates in the Progression and Prognosis of Advanced Gastric CancerSemantic proximity Read ↗

Identification of gastric cancer subtypes based on pathway clusteringSemantic proximity Read ↗

Development of Tumor Mutation Burden-Related Prognostic Model and Novel Biomarker Identification in Stomach AdenocarcinomaSemantic proximity Read ↗

An immune signature for risk stratification and therapeutic prediction in helicobacter pylori-infected gastric cancerSemantic proximity Read ↗

Mutations Defining Patient Cohorts With Elevated PD-L1 Expression in Gastric CancerSemantic proximity Read ↗

A 15-DNA Repair Gene Prognostic Signature for Immunotherapy in Gastric CancerSemantic proximity Read ↗

Somatic mutations that affect early genetic progression and immune microenvironment in gastric carcinoma.Semantic proximity Read ↗

A novel pathway mutation perturbation score predicts the clinical outcomes of immunotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.