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Article

Shared genetic architecture between depression and migraine: a large-scale genome-wide cross-trait analysis.

The journal of headache and pain - 25 May 2026

Zhang Min, Li Qiyin, Zhao Yuan, Peng Yadong, Yu Jiangyou, Gan Cheng, Tang Liwei, Liu Keyi, Liu Ying, Zhang Zheng, Wang Xinglian, Tang Mingshuang, Jiang Chenggang, Gu Dongqing

Abstract excerpt

BACKGROUND: Depression and migraine are highly prevalent neuropsychiatric disorders that frequently co-occur. However, the extent to which they share genetic determinants, particularly for postpartum depression (PPD), an underexplored subtype, remains insufficiently understood. METHODS: We performed a large-scale genome-wide cross-trait analysis using summary statistics for depression phenotypes (overall...

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Identifiers

PMID: 42185775
DOI: 10.1186/s10194-026-02402-2
PMCID: PMC13390404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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