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Article

Do Common Genetic Factors Underlie Comorbidity Between Migraine and Major Depressive Disorder in Youth?

Pediatric neurology - 1 Dec 2025

Merikangas Alison K, Schultz Laura M, Ruparel Kosha, Lateef Tarannum, Gur Raquel E, Almasy Laura

Abstract excerpt

BACKGROUND: Migraine and major depressive disorder (MDD) are common, recurring conditions with comorbidity documented in clinical and community samples of both adults and youth. However, the etiology remains unknown. This study aims to (1) examine the prevalence and association between migraine and MDD in a large, diverse youth sample; (2) assess whether polygenic scores (PGSs) from adult genome-wide association...

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Identifiers

PMID: 41135260
DOI: 10.1016/j.pediatrneurol.2025.09.017
PMCID: PMC12674002

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