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Article

Genetic overlap and causality between depression and preterm birth: a large-scale genome-wide cross-trait analysis.

Psychological medicine - 25 Sept 2025

Zhang Min, Chen Xinzhen, Zhou Wenzheng, Zhou Niya, Zhang Cuihua, Yang Yunping, Li Qiyin, Ming Xin, Wu Yifu, Qi Hongbo, Zhou Wei

Abstract excerpt

BACKGROUND: Little is known regarding the shared genetic architecture underlying the phenotypic associations between depression and preterm birth (PTB). We aim to investigate the genetic overlap and causality of depression with PTB. METHODS: Leveraging summary statistics from the largest genome-wide association studies for broad depression (Ntotal = 807,533), major depression (Ntotal = 173,005), bipolar disorder...

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Identifiers

PMID: 40995647
DOI: 10.1017/S0033291725100718
PMCID: PMC12527502

Genes

DRD2
NCAM1

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