Article
Signals from the bone marrow B cell niches shape pre-leukemic fate in a murine model of B cell acute lymphoblastic leukemia.
Oncogene - 1 Jul 2026
Delahaye Marjorie C, Léonard Simon, Pelletier Jeoffrey, Destin Jérôme, Bardin Florence, Ounis Mourad, Monvoisin Céline, Prade Naïs, Gil Laurine, Dauba Audrey, Milpied Pierre, Khamlichi Ahmed Amine, Delabesse Eric, Marchand Tony, Broccardo Cyril, Aurrand-Lions Michel, Gerby Bastien, Mancini Stéphane Jc
Abstract excerpt
The bone marrow (BM) microenvironment plays a key role in supporting B cell development. In acute lymphoblastic leukemia (B-ALL), the acquisition of oncogenic driver mutations blocks B cell differentiation at specific stages. When these pre-leukemic cells acquire secondary mutations, B-ALL develops. However, the role of the BM microenvironment in pre-leukemic cell fate remains unknown. Here, using a murine model...
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