Article
Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia.
Nature medicine - 1 Jun 2005
Castor Anders, Nilsson Lars, Astrand-Grundström Ingbritt, Buitenhuis Miranda, Ramirez Carole, Anderson Kristina, Strömbeck Bodil, Garwicz Stanislaw, Békássy Albert N, Schmiegelow Kjeld, Lausen Birgitte, Hokland Peter, Lehmann Sören, Juliusson Gunnar, Johansson Bertil, Jacobsen Sten Eirik W
Abstract excerpt
The cellular targets of primary mutations and malignant transformation remain elusive in most cancers. Here, we show that clinically and genetically different subtypes of acute lymphoblastic leukemia (ALL) originate and transform at distinct stages of hematopoietic development. Primary ETV6-RUNX1 (also known as TEL-AML1) fusions and subsequent leukemic transformations were targeted to committed B-cell...
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