Article
NS1-A53D enhances HA stability to coordinate viral entry with vRNP export and replication during adaptation of H1N1 canine influenza virus.
Veterinary microbiology - 1 Jul 2026
Zhu Min, Wang Rang, Li Xiaolong, Zhou Yefan, Peng Linying, Wang Pingping, Zhou Huabo, Huang Jianni, Qin Yifeng, Ouyang Kang, Yin Yeshi, Wei Zuzhang, Huang Weijian, Chen Ying
Abstract excerpt
Eurasian avian-like H1N1 influenza A viruses that have reassorted with the 2009 pandemic H1N1 virus pose a potential public health threat. We previously reported that synergistic mutations in HA and NS genes enhanced the virulence of a mouse-adapted EA H1N1 canine influenza virus (CIV), yet the underlying mechanisms remained unclear. Here, we demonstrate that the adaptive mutations NS1-A53D and NEP-R42K...
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