Article

A Conserved NP Mutation Quartet Drives the Avian-to-Canine Host Jump and Establishes a Molecular Foundation for Zoonotic Adaptation

2026-02-25

Abstract excerpt

<title>Abstract</title> <p>Understanding the molecular principles of influenza A virus (IAV) host-switching remains a fundamental challenge, as many landmark spillovers occurred before the era of high-resolution genomics. Here, we demonstrate that H3N2 canine influenza virus (CIV) provides a uniquely powerful evolutionary proxy to resolve the real-time molecular logic of host-switching. As a paradigm of rapid avi...

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Literature Corpus work: b2824d0b-2e3c-5d41-80ca-004eba891f6e
DOI: 10.21203/rs.3.rs-8797160/v1

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