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Article

Mendelian randomization analysis links HLA-DR+ CD14- CD16+ monocytes to CCL19-driven ankylosing spondylitis risk.

Medicine - 8 May 2026

Bei Liyuan, Liao Jing, Tan Chunlan, Li Xian, Yang Zhenhua

Abstract excerpt

Ankylosing spondylitis (AS), strongly linked to human leukocyte antigen (HLA)-B27, lacks effective treatments for many patients despite biologics. This study investigated causal links between immune cells, inflammatory proteins, and AS to identify new therapeutic targets using genetic methods. Mendelian randomization (MR) analysis was applied using large-scale genetic data. Immune cell data came from Vuckovic et...

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Share to GPI-Linked Proteins
Share to HLA-B27 Antigen
Share to HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipopolysaccharide Receptors

Share to Mendelian Randomization Analysis

Share to Monocytes

Share to Receptors, IgG

Share to Spondylitis, Ankylosing

Source

Open in PubMed Open full text

Identifiers

PMID: 42116383
DOI: 10.1097/MD.0000000000048687
PMCID: PMC13166580

Genes

CCL19
CD14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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