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Article

Effects of Immune Cells and Plasma Metabolites on Osteoarthritis: A Mediation Mendelian Randomization Study.

International journal of rheumatic diseases - 1 Feb 2026

Huang Changfa, Fan Hao, Zheng Zhifa, Ma Wenjing, Wei Ze, Han Huitian, Liang Annan, Mu Xuemeng, Zou Wei, Hao Jing, Liu Fei, Liu Lijin, Liu Su, Zhao Lina, Wu Zhihong

Abstract excerpt

OBJECTIVE: Recent studies suggest that immune cells and plasma metabolites may play significant roles in osteoarthritis pathogenesis. However, the causal relationships between these factors and osteoarthritis are unclear. METHODS: Based on the genome-wide association study (GWAS) database, 731 immune cell phenotypes and 1400 metabolites were evaluated for their possible mediating effects on osteoarthritis via...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41603078
DOI: 10.1111/1756-185x.70447

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CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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