Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants affect diurnal glucose levels throughout the day.

Nature communications - 22 May 2026

Sinnott-Armstrong Nasa, Strausz Satu, Urpa Lea, Abner Erik, Johnson Josephine P, Valliere Jesse, Palumaa Teele, Palta Priit, Dashti Hassan S, Chang Kyong-Mi, Vujkovic Marijana, Daly Mark, Pritchard Jonathan K, Saxena Richa, Jones Samuel E, Ollila Hanna M

Abstract excerpt

Circadian rhythms not only coordinate the timing of wake and sleep but also regulate homeostasis within the body, including glucose metabolism. The genetic variants that contribute to the temporal control of glucose levels have not been previously examined. Using genome-wide data from ~420,000 individuals from the UK Biobank and replication in ~100,000 individuals from the Estonian Biobank, ~500,000 from FinnGen,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Circadian Rhythm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cryptochromes

Share to Diabetes Mellitus, Type 2

Share to Glucose

Share to Melatonin

Share to Receptor, Melatonin, MT2

Source

Open in PubMed Open full text

Identifiers

PMID: 42173832
DOI: 10.1038/s41467-026-72432-6
PMCID: PMC13385737

Genes

CRY2
MTNR1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants affect diurnal glucose levels throughout the day.PMID 42173832Read ↗

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythmsSemantic proximity Read ↗

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to diseaseSemantic proximity Read ↗

Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study.Semantic proximity Read ↗

Variants in MTNR1B influence fasting glucose levels.Semantic proximity Read ↗

The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story.Semantic proximity Read ↗

Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.Semantic proximity Read ↗

Genome-wide association analyses in > 119,000 individuals identifies thirteen morningness and two sleep duration lociSemantic proximity Read ↗

Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.Semantic proximity Read ↗

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration LociSemantic proximity Read ↗

Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits.Semantic proximity Read ↗

Tired of diabetes genetics? Circadian rhythms and diabetes: the MTNR1B story?Semantic proximity Read ↗

Single nucleotide polymorphisms (SNPs) in circadian genes: Impact on gene function and phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.