Article
Single nucleotide polymorphisms (SNPs) in circadian genes: Impact on gene function and phenotype.
Advances in protein chemistry and structural biology - 1 Jan 2023
Baris Ibrahim, Ozcan Onur, Kavakli Ibrahim Halil
Abstract excerpt
Circadian rhythm is an endogenous timing system that allows an organism to anticipate and adapt to daily changes and regulate various physiological variables such as the sleep-wake cycle. This rhythm is governed by a molecular circadian clock mechanism, generated by a transcriptional and translational feedback loop (TTFL) mechanism. In mammals, TTFL is determined by the interaction of four main clock proteins:...
Topics
- Humans
- Animals
- Polymorphism, Single Nucleotide
- ARNTL Transcription Factors
- Phenotype
- Cryptochromes
- Cytosol
- Polymers
- Mammals