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Article

Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study.

Diabetologia - 1 May 2015

Renström Frida, Koivula Robert W, Varga Tibor V, Hallmans Göran, Mulder Hindrik, Florez Jose C, Hu Frank B, Franks Paul W

Abstract excerpt

AIMS/HYPOTHESIS: The association of single nucleotide polymorphisms (SNPs) proximal to CRY2 and MTNR1B with fasting glucose is well established. CRY1/2 and MTNR1B encode proteins that regulate circadian rhythmicity and influence energy metabolism. Here we tested whether season modified the relationship of these loci with blood glucose concentration. METHODS: SNPs rs8192440 (CRY1), rs11605924 (CRY2) and rs10830963...

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Source

Identifiers

PMID: 25707907
DOI: 10.1007/s00125-015-3533-8

Genes

CRY1
CRY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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