Article
Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.
Diabetes - 1 Nov 2009
Chambers John C, Zhang Weihua, Zabaneh Delilah, Sehmi Joban, Jain Piyush, McCarthy Mark I, Froguel Philippe, Ruokonen Aimo, Balding David, Jarvelin Marjo-Riitta, Scott James, Elliott Paul, Kooner Jaspal S
Abstract excerpt
OBJECTIVE: Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians. RESEARCH DESIGN AND METHODS: We carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the Illumina Hap610 BeadChip...
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