Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.

doi:10.2337/db15-0999

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Article

Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.

Diabetes - 1 Jun 2016

Lane Jacqueline M, Chang Anne-Marie, Bjonnes Andrew C, Aeschbach Daniel, Anderson Clare, Cade Brian E, Cain Sean W, Czeisler Charles A, Gharib Sina A, Gooley Joshua J, Gottlieb Daniel J, Grant Struan F A, Klerman Elizabeth B, Lauderdale Diane S, Lockley Steven W, Munch Miriam, Patel Sanjay, Punjabi Naresh M, Rajaratnam Shanthakumar M W, Rueger Melanie, St Hilaire Melissa A, Santhi Nayantara, Scheuermaier Karin, Van Reen Eliza, Zee Phyllis C, Shea Steven A, Duffy Jeanne F, Buxton Orfeu M, Redline Susan, Scheer Frank A J L, Saxena Richa

Abstract excerpt

The risk of type 2 diabetes (T2D) is increased by abnormalities in sleep quantity and quality, circadian alignment, and melatonin regulation. A common genetic variant in a receptor for the circadian-regulated hormone melatonin (MTNR1B) is associated with increased fasting blood glucose and risk of T2D, but whether sleep or circadian disruption mediates this risk is unknown. We aimed to test if MTNR1B diabetes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26868293
DOI: 10.2337/db15-0999
PMCID: PMC4878414

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