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Article

Study on NGS-based molecular profiling of malignant pleural effusion supernatant cfDNA in guiding targeted therapy for non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2026

Wang Yuan, Liang Shuo, Zhang Jia-Meng, Sun Zi-Han, Li Wei-Hua, Sun Yue, Wang Cong, Chang Xin-Xiang, Zhao Lin-Lin, Zhao Huan, Guo Hui-Qin, Zhang Zhi-Hui

Abstract excerpt

BACKGROUND: For patients with advanced non-small cell lung cancer (NSCLC), obtaining histological specimens can be challenging due to the presence of malignant pleural effusion (MPE), making liquid biopsy an important alternative for molecular profiling. This study aims to comparatively analyze the advantages of MPE supernatant over other sample types in molecular testing and to assess the feasibility and...

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Source

Identifiers

PMID: 42172737
DOI: 10.1016/j.lungcan.2026.109463

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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