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Enhanced detection of actionable mutations in NSCLC through pleural effusion cell-free DNA sequencing: A prospective study

7 Jan 2025

Abstract excerpt

BACKGROUND: Inadequate tumour samples often hinder molecular testing in non-small cell lung cancer (NSCLC). Plasma-based cell-free DNA (cfDNA) sequencing has shown promise in bypassing these tissue limitations. Nevertheless, pleural effusion (PE) samples may offer a richer cfDNA source for mutation detection in patients with malignant PE. METHODS: This prospective study enrolled newly diagnosed advanced NSCLC...

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PMID: 39799785
DOI: 10.1016/j.ejca.2025.115224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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