Article
Multigene PCR using both cfDNA and cfRNA in the supernatant of pleural effusion achieves accurate and rapid detection of mutations and fusions of driver genes in patients with advanced NSCLC.
Cancer medicine - 1 Apr 2021
Chen Xuejing, Li Kun, Liu Zichen, Gai Fei, Zhu Guanshan, Lu Shun, Che Nanying
Abstract excerpt
BACKGROUND: Pleural effusion from patients with advanced non-small cell lung cancer (NSCLC) has been proved valuable for molecular analysis, especially when the tissue sample not available. However, simultaneous detection of multiple driver gene alterations especially the fusions is still challenging. METHODS: In this study, 77 patients with advanced NSCLC and pleural effusion were enrolled, 49 of whom had...
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