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Analysis of EGFR mutation status in malignant pleural effusion and plasma from patients with advanced lung adenocarcinoma.

Clinical chemistry and laboratory medicine - 27 Aug 2020

Son Seung-Myoung, Woo Chang Gok, Han Hye Sook, Lee Ki Hyeong, Lim Young Hyun, Lee Ok-Jun

Abstract excerpt

Background: Cell-free DNA (cfDNA) is emerging as a surrogate sample type for mutation analyses. We investigated the suitability of malignant pleural effusion (MPE) and plasma as a biomaterial for analyzing epidermal growth factor receptor (EGFR) mutation by peptide nucleic acid (PNA) clamping-assisted fluorescence melting curve (PANAMutyper™) analysis. Methods: Matched tissue, MPE cell block (MPE-CB), MPE...

Topics

Adenocarcinoma of Lung
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Circulating Tumor DNA
ErbB Receptors
Female
Humans
Lung Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Pleural Effusion, Malignant

Source

Identifiers

PMID: 32229655
DOI: 10.1515/cclm-2019-1139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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