Article
High Yield of Pleural Cell-Free DNA for Diagnosis of Oncogenic Mutations in Lung Adenocarcinoma.
Chest - 1 Jul 2023
Mahmood Kamran, Jampani Parvathi, Clarke Jeffrey M, Wolf Steven, Wang Xiaofei, Wahidi Momen M, Giovacchini Coral X, Dorry Michael, Shofer Scott L, Shier Jessica, Jones Greg, Antonia Scott J, Nixon Andrew B
Abstract excerpt
BACKGROUND: Pleural cytology is currently used to assess targetable mutations in patients with advanced lung adenocarcinoma. However, it is fraught with low diagnostic yield. RESEARCH QUESTION: Can pleural cell-free DNA (cfDNA) be used to assess targetable mutations in lung adenocarcinoma patients with malignant pleural effusions (MPE)? STUDY DESIGN AND METHODS: Patients with lung adenocarcinoma MPE were...
Topics
- Humans
- Cell-Free Nucleic Acids
- Adenocarcinoma of Lung
- Lung Neoplasms
- Pleural Effusion, Malignant
- Mutation