Article
Clinical utility of pleural effusion supernatant cell-free DNA genotyping in previously treated patients with advanced non-small-cell lung cancer and disease progression: a multicenter retrospective study.
ESMO open - 1 Jan 2026
Chang S-C, Huang C-Y, Lai Y-C, Hsieh M-S, Ho C-C, Yang C-Y, Shih J-Y, Wu S-G, Hu P-W, Hsu C-L, Chen C-Y, Liao W-Y
Abstract excerpt
BACKGROUND: Patients with lung cancer frequently develop pleural effusion as the disease progresses. This study evaluated the utility of cell-free DNA (cfDNA) from pleural effusion supernatant in identifying targetable mutations in non-small-cell lung cancer (NSCLC) patients who developed resistance to prior therapies. METHODS: We conducted a multicenter retrospective study involving 95 patients who experienced...
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