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Article

Clinicogenomic Landscape of MTAP-Deleted Thoracic Malignancies Across US and Japanese Nationwide Cohorts: Impact of Concurrent CDKN2A Alterations and Driver Mutations.

JCO precision oncology - 1 May 2026

Ikushima Hiroaki, Watanabe Kousuke, Shinozaki-Ushiku Aya, Oda Katsutoshi, Kage Hidenori

Abstract excerpt

PURPOSE: Methylthioadenosine phosphorylase (MTAP) deletion represents a promising therapeutic vulnerability through synthetic lethality. However, the clinical and molecular context of MTAP-deleted thoracic tumors, particularly with respect to actionable oncogenic drivers and immune checkpoint inhibitor efficacy, remains incompletely defined across diverse populations. METHODS: We analyzed clinicogenomic data from...

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Source

Identifiers

PMID: 42172559
DOI: 10.1200/PO-26-00100

Genes

MTAP
CAT
CDKN2A
EGFR
ALK
ERBB2
RB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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