Comprehensive Genomic and Transcriptomic Characterization of MTAP Loss across Advanced Solid Tumors.

doi:10.1158/1078-0432.CCR-25-4936

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Article

Comprehensive Genomic and Transcriptomic Characterization of MTAP Loss across Advanced Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Aug 2026

Seguchi Kyosuke, Fujisawa Takao, Ikeda Sadakatsu, Oyama Yu, Nonomura Norio, Morizane Chigusa, Iwata Hiroji, Okano Susumu, Watari Hidemichi, Namikawa Kenjiro, Kadowaki Shigenori, Ueno Makoto, Oki Eiji, Boku Shogen, Yuki Satoshi, Yamagami Wataru, Nishina Tomohiro, Kudo Toshihiro, Takahashi Naoki, Bando Hideaki, Yoshino Takayuki, Nakamura Yoshiaki

Abstract excerpt

PURPOSE: Methylthioadenosine phosphorylase (MTAP) is a tumor suppressor gene, with loss of MTAP occurring in approximately 15% of solid tumors; however, its molecular and clinicopathologic significance remains incompletely defined. EXPERIMENTAL DESIGN: We conducted a multicenter observational study using two nationwide Japanese genomic screening programs, defining MTAP loss as homozygous deletion. In the...

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Identifiers

PMID: 42148883
DOI: 10.1158/1078-0432.CCR-25-4936
PMCID: PMC13430230

Genes

MTAP
CDKN2A

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