Article
Somatic and germline genomic variation in thymic carcinomas.
ESMO open - 1 Mar 2026
Tettamanzi F, De Carlo C, Cappadona C, Giuliano D, Rimoldi V, Piombo C, Cecchi L G, Zanella S, Marulli G, Voulaz E, Veronesi G, Marchini S, Di Tommaso L, Zucali P A, Asselta R
Abstract excerpt
BACKGROUND: Thymic carcinoma (TC) is a rare and aggressive neoplasm of thymic epithelial origin, with no currently available biomarkers to guide treatment or prognosis. In this study, we aimed at characterizing the genomic landscape of a cohort of TCs, at somatic and germline levels. MATERIALS AND METHODS: Whole-exome sequencing was carried out on 25 TC archival samples and 17 histologically normal adjacent...
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