Kinetics and Spatial Distribution of β-Sheet Development in TDP-43CTD Condensate Maturation.

doi:10.1021/acschemneuro.6c00226

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Article

Kinetics and Spatial Distribution of β-Sheet Development in TDP-43CTD Condensate Maturation.

ACS chemical neuroscience - 3 Jun 2026

Ramos Sashary, Watson Matthew D, Lee Jennifer C

Abstract excerpt

Cytosolic inclusions of aggregated TAR DNA-binding protein 43 (TDP-43) are hallmarks of neurodegenerative disorders such as amyotrophic lateral sclerosis and frontotemporal lobar dementia. A prevailing hypothesis suggests that TDP-43 condensates undergo a liquid-to-solid transition during maturation, involving the formation of β-sheet-rich, amyloid-like aggregates. To test this hypothesis, we sought to study the...

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PMID: 42171508
DOI: 10.1021/acschemneuro.6c00226
PMCID: PMC13237731

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