Article

Structural Biophysics-Guided Computational Design of Semaglutide Analogues to Enhance GLP-1R Activation

2024-12-03

Abstract excerpt

CagriSema is a fixed-dose combination of cagrilintide (an amylin analogue) and semaglutide (a GLP-1 receptor agonist), and is currently an experimental obesity drug developed by Novo Nordisk. In March, 2025, CagriSema underperformed expectations in a Phase III trial, achieving 15.7% weight loss instead of the anticipated 25%, raising concerns about its efficacy and clinical value. Given its chemical composition, t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b3660a8-d17b-5198-990c-28ca25844e89
DOI: 10.1101/2024.11.29.625980

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural Biophysics-Guided Computational Design of Semaglutide Analogues to Enhance GLP-1R ActivationDOI 10.1101/2024.11.29.625980Read

Structural Biophysics-Guided Computational Design of Semaglutide Analogues to Enhance GLP-1R ActivationSemantic proximity Read

Molecular dynamics-guided optimization of BGM0504 enhances dual-target agonism for combating diabetes and obesitySemantic proximity Read

Blind De Novo Design of Dual Cyclic Peptide Agonists Targeting GCGR and GLP1RSemantic proximity Read

Pharmacogenomics of GLP-1 Receptor Agonists: Precision Medicine in the Age of Ozempic and MounjaroSemantic proximity Read

Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistanceSemantic proximity Read

Generation of High-Affinity Anti-GIPR Antagonist Antibodies with Sustained and Non-rebound Weight Loss in DIO Mice by AlfaBodYSemantic proximity Read

Molecular Dynamics Insights into the Binding Interactions of Semaglutide with Human Serum AlbuminSemantic proximity Read

Tuning Insulin Receptor Signaling Using <i>De Novo</i> Designed AgonistsSemantic proximity Read

Influence of GLP1 receptor rs6923761 and rs761387 genetic variants on oral semaglutide response in patients with type 2 diabetes.Semantic proximity Read

Complete characterization of the mutation landscape reveals the effect on amylin stability and amyloidogenicity.Semantic proximity Read

<i>In vivo</i> functional profiling and structural characterisation of the human <i>Glp1r</i> A316T variantSemantic proximity Read

Mapping Structural Drivers of Insulin Analogs Using Molecular Dynamics and Free Energy Calculations at Insulin ReceptorSemantic proximity Read