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Article

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.

The Journal of cell biology - 1 Apr 2013

Srikumar Tharan, Lewicki Megan C, Costanzo Michael, Tkach Johnny M, van Bakel Harm, Tsui Kyle, Johnson Erica S, Brown Grant W, Andrews Brenda J, Boone Charles, Giaever Guri, Nislow Corey, Raught Brian

Abstract excerpt

Like ubiquitin, the small ubiquitin-related modifier (SUMO) proteins can form oligomeric "chains," but the biological functions of these superstructures are not well understood. Here, we created mutant yeast strains unable to synthesize SUMO chains (smt3(allR)) and subjected them to high-content microscopic screening, synthetic genetic array (SGA) analysis, and high-density transcript profiling to perform the...

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Identifiers

PMID: 23547032
DOI: 10.1083/jcb.201210019
PMCID: PMC3613684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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