Article
A New CA19-9 Cutoff Value Identifies Lewis Antigen Status and Refines Prognostic Stratification in PDAC.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2026
Yeh Chia-Ming, Yu Chih-Chuan, Lee An-Fu, Cheng Siao Muk, Hsu Che-Wei, Chiang Nai-Jung, Hou Ya-Chin, Tsai Hui-Jen, Chen Shang-Hung, Yen Chia-Jui, Wang Chih-Jung, Chao Ying-Jui, Chuang Shih-Chang, Du Jeng-Shiun, Hwang Daw-Yang, Shan Yan-Shen, Chen Li-Tzong, Su Yung-Yeh
Abstract excerpt
PURPOSE: Carbohydrate antigen 19-9 (CA19-9) has limited utility in the ∼10% of patients with pancreatic ductal adenocarcinoma (PDAC) who are Lewis-negative CA19-9 "nonproducers" (FUT3-null). This study aims to define the prognosis of FUT3-null PDAC and establish a CA19-9 cutoff that can help identify this subgroup in clinical practice. EXPERIMENTAL DESIGN: Germline whole-exome sequencing was performed in a...
Topics
- Aged
- Female
- Humans
- Male
- Middle Aged
- Biomarkers, Tumor
- CA-19-9 Antigen
- Carcinoma, Pancreatic Ductal
- Exome Sequencing