Article
Optimize CA19-9 in detecting pancreatic cancer by Lewis and Secretor genotyping.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2000
Luo Guopei, Guo Meng, Jin Kaizhou, Liu Zuqiang, Liu Chen, Cheng He, Lu Yu, Long Jiang, Liu Liang, Xu Jin, Ni Quanxing, Yu Xianjun
Abstract excerpt
BACKGROUND: Carbohydrate antigen 19-9 (CA19-9) is currently the most widely used biomarker for pancreatic cancer. It is well-known that Lewis and Secretor status can affect CA19-9 biosynthesis. This study was performed to optimize CA19-9 in detecting pancreatic cancer using Lewis and Secretor dependent cut-off values. METHODS: Lewis and Secretor genotypes were determined by Sanger sequencing in a large cohort of...
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