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Article

Using Tumor Marker Gene Variants to Improve the Diagnostic Accuracy of DUPAN-2 and Carbohydrate Antigen 19-9 for Pancreatic Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2024

Ando Yohei, Dbouk Mohamad, Yoshida Takeichi, Saba Helena, Abou Diwan Elizabeth, Yoshida Kanako, Dbouk Ali, Blackford Amanda L, Lin Ming-Tseh, Lennon Anne Marie, Burkhart Richard A, He Jin, Sokoll Lori, Eshleman James R, Canto Marcia Irene, Goggins Michael

Abstract excerpt

PURPOSE: Circulating carbohydrate antigen 19-9 (CA19-9) levels reflect FUT3 and FUT2 fucosyltransferase activity. Measuring the related glycan, DUPAN-2, can be useful in individuals unable to synthesize CA19-9. We hypothesized that similar to CA19-9, FUT functional groups determined by variants in FUT3 and FUT2 influence DUPAN-2 levels, and having tumor marker reference ranges for each functional group would...

Topics

Humans
Pancreatic Neoplasms
Fucosyltransferases
CA-19-9 Antigen
Biomarkers, Tumor
Middle Aged
Female
Male
Galactoside 2-alpha-L-fucosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Carcinoma, Pancreatic Ductal

Aged

Genotype

Sensitivity and Specificity

Antigens, Neoplasm

Source

Open in PubMed Open full text

Identifiers

PMID: 38457748
DOI: 10.1200/JCO.23.01573
PMCID: PMC11191066

Genes

FUT3
FUT2
CAPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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