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The rotavirus cVLPVP8∗ vaccine candidate induces cross-genotype/heterotypic neutralizing antibody responses against human rotavirus G9P[4].

Virology - 1 Aug 2026

Behnezhad Farzane, Ataei-Pirkooh Angila, Kachooei Atefeh, Golsaz-Shirazi Forough, Arashkia Arash, Mir-Hosseinian Mahtab, Hosseini-Fakhr Somayeh-Sadat, Mousavizadeh Leila, Jalilvand Somayeh, Roohvand Farzin, Shoja Zabihollah

Abstract excerpt

Live oral rotavirus (RV) vaccines show variable efficacy and safety profiles, particularly in low- and middle-income countries (LMICs). We have developed a chimeric hepatitis B core parenteral virus-like particle displaying VP8∗P[8] RV vaccine antigen (cVLPVP8∗) capable of inducing VP8∗- specific serum neutralizing antibodies (nAbs). The immunogenicity of cVLPVP8∗ and its potential to induce...

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Identifiers

PMID: 42161115
DOI: 10.1016/j.virol.2026.110957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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