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Bivalent rotavirus VP4∗ stimulates protective antibodies against common genotypes of human rotaviruses

8 Sept 2022

Abstract excerpt

Non-replicating rotavirus vaccines are an alternative strategy to improve the efficacy and safety of rotavirus vaccines. The spike protein VP4, which could be enzymatically cleaved into VP8∗ and VP5∗, is an ideal target for the development of recombinant rotavirus vaccine. In our previous studies, we demonstrated that the truncated VP4 (aa26-476, VP4∗) could be a more viable vaccine candidate compared to VP8∗ and...

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PMID: 36185383
DOI: 10.1016/j.isci.2022.105099

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