Article
A rotavirus VP4 or VP7 monoreassortant panel identifies genotypes that are less susceptible to neutralization by systemic antibodies induced by vaccination or natural infection.
mBio - 9 Jul 2025
Kotaki Tomohiro, Kanai Yuta, Ogden Kristen M, Onishi Megumi, Kumthip Kattareeya, Khamrin Pattara, Boonyos Patcharaporn, Phoosangwalthong Pornkamol, Singchai Phakapun, Luechakham Tipsuda, Minami Shohei, Chen Zelin, Hirai Katsuhisa, Tacharoenmuang Ratana, Mizushima Hiroto, Ushijima Hiroshi, Maneekarn Niwat, Kobayashi Takeshi
Abstract excerpt
Rotavirus infections remain a significant cause of morbidity and mortality in infants. The viral surface proteins VP4 and VP7 are each classified into multiple genotypes (P[1]-P[58] for VP4 and G1-G42 for VP7), which differ in their susceptibility to neutralizing antibodies; however, detailed analyses of these differences remain limited. This study investigates the susceptibility of diverse VP4 and VP7 genotypes...
Topics
- Antibodies, Neutralizing
- Capsid Proteins
- Rotavirus
- Humans
- Genotype
- Antigens, Viral
- Antibodies, Viral
- Rotavirus Infections
- Rotavirus Vaccines