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Article

Monovalent Rotavirus Vaccine Efficacy Against Different Rotavirus Genotypes: A Pooled Analysis of Phase II and III Trial Data.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 8 Feb 2023

Amin Avnika B, Tate Jacqueline E, Waller Lance A, Lash Timothy L, Lopman Benjamin A

Abstract excerpt

BACKGROUND: Rotavirus vaccine performance appears worse in countries with high rotavirus genotype diversity. Evidence suggests diminished vaccine efficacy (VE) against G2P[4], which is heterotypic with existing monovalent rotavirus vaccine formulations. Most studies assessing genotype-specific VE have been underpowered and inconclusive. METHODS: We pooled individual-level data from 10 Phase II and III clinical...

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Identifiers

PMID: 36031386
DOI: 10.1093/cid/ciac699
PMCID: PMC10169401

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