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Article

Chimeric virus-like particles of human norovirus constructed by structure-guided epitope grafting elicit cross-reactive immunity against both GI.1 and GII.4 genotypes.

Journal of virology - 31 Oct 2023

Hou Ya Nan, Jin Yu Qin, Zhang Xue Feng, Tang Fang, Hou Jun Wei, Liu Zhao Ming, Han Zi Bo, Zhang Hao, Du Li Fang, Shao Shuai, Su Ji Guo, Liang Yu, Zhang Jing, Li Qi Ming

Abstract excerpt

IMPORTANCE: Human norovirus (HuNoV) is highly infectious and can result in severe illnesses in the elderly and children. So far, there is no effective antiviral drug to treat HuNoV infection, and thus, the development of HuNoV vaccines is urgent. However, NoV evolves rapidly, and currently, at least 10 genogroups with numerous genotypes have been found. The genetic diversity of NoV and the lack of...

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Identifiers

PMID: 37792003
DOI: 10.1128/jvi.00938-23
PMCID: PMC10617407

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