Article

Transmission cycles generate diversity in pathogenic viruses

2018-06-07

Abstract excerpt

We investigate the fate of de novo mutations that occur during the in-host replication of a pathogenic virus, predicting the probability that such mutations are passed on during disease transmission to a new host. Using influenza A virus as a model organism, we develop a life-history model of the within-host dynamics of the infection, using a multitype branching process with a coupled deterministic model to captu...

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Identifiers and source

Literature Corpus work: 5c2f0bb4-3b62-5587-afad-d758a1c8af05
DOI: 10.1101/339861

Open publication

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