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Article

Genotype-associated outcomes after deep brain stimulation in Parkinson's disease: a systematic review, meta-analysis and epigenetic implications.

Neurologia i neurochirurgia polska - 1 Jan 2026

Limanówka Bartosz, Lisman Dagmara, Sagan Leszek

Abstract excerpt

INTRODUCTION: Deep brain stimulation (DBS) is an established treatment for advanced Parkinson's disease (PD), but outcomes in genotype-defined PD remain debated. GBA1 variants are associated with faster cognitive decline, while their impact on DBS motor benefit is less clear. STATE OF THE ART: To assess whether DBS motor response differs by genotype in PD by pooling change in Unified Parkinson's Disease Rating...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41823280
DOI: 10.5603/pjnns.110289

Genes

GBA1
PRKN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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