Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early motor response to dopamine replacement therapy in Parkinson's disease patients carrying GBA variants.

Journal of the neurological sciences - 15 Sept 2022

Rossi Malco, Castillo-Torres Sergio A, Merello Marcelo

Abstract excerpt

BACKGROUND: Mutations in the glucocerebrosidase (GBA) gene represent the most common genetic risk factor for Parkinson's Disease (PD) and are associated with a more aggressive motor phenotype at late stages. However, the motor response at early stages of disease remains understudied. METHODS: Retrospective study of PD patients that underwent next-generation sequencing panel tests for PD-related genes. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopamine
Share to Glucosylceramidase
Share to Levodopa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Parkinson Disease

Source

Identifiers

PMID: 35907343
DOI: 10.1016/j.jns.2022.120354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early motor response to dopamine replacement therapy in Parkinson's disease patients carrying GBA variants.PMID 35907343Read ↗

Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease.Semantic proximity Read ↗

Faster disease progression in Parkinson's disease with glucocerebrosidase genotype: But not apparent immediate from diagnosis.Semantic proximity Read ↗

GBA-associated PD: chances and obstacles for targeted treatment strategies.Semantic proximity Read ↗

Association of GBA genotype with motor and cognitive decline in Chinese Parkinson’s disease patientsSemantic proximity Read ↗

Effects of GBA1 Variants in Patients With Parkinson's Disease and Levodopa-Carbidopa Intestinal Gel: A Nation-Wide, Multicenter, Longitudinal, "Real-World" Study. The EPIC Study.Semantic proximity Read ↗

GBA, Gaucher Disease, and Parkinson’s Disease: From Genetic to Clinic to New Therapeutic ApproachesSemantic proximity Read ↗

Glucocerebrosidase Mutations and Motor Reserve in Parkinson's Disease.Semantic proximity Read ↗

The Molecular Impact of Glucosylceramidase Beta 1 (Gba1) in Parkinson's Disease: a New Genetic State of the Art.Semantic proximity Read ↗

Clinical, PET/CT, and Longitudinal Progression Characteristics of GBA-Associated Parkinson’s Disease in a Northeast China CohortSemantic proximity Read ↗

Precision medicine in Parkinson's disease patients with LRRK2 and GBA risk variants - Let's get even more personal.Semantic proximity Read ↗

Evolution of prodromal parkinsonian features in a cohort ofGBAmutation-positive individuals: a 6-year longitudinal studySemantic proximity Read ↗

GBA1-and LRRK2-directed Treatments: The Way Forward.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.