Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Platelet/Megakaryocyte Axis is Necessary for Allergic Sensitisation and Inflammatory Responses to House Dust Mite in the Lung.

Lung - 19 May 2026

Chalidou Anna, Case Katie-Marie, Hobbs Carl, Page Clive P, Pitchford Simon C

Abstract excerpt

BACKGROUND: Evidence demonstrates that megakaryocytes (MKs) possess antigen processing and presentation properties. We investigated whether sensitisation to house dust mite (HDM) extract and the establishment of allergic pulmonary inflammation was dependent on the presence of platelets, and whether the allergic phenotype had an effect on antigen-presenting marker expression on MKs and platelets. METHODS: Balb/c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchoalveolar Lavage Fluid
Share to Interleukin-13

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-4

Share to Megakaryocytes

Share to Pneumonia

Share to Pyroglyphidae

Share to Receptors, IgE

Share to Th2 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 42154289
DOI: 10.1007/s00408-026-00896-w
PMCID: PMC13186874

Genes

CD4
CD40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Platelet/Megakaryocyte Axis is Necessary for Allergic Sensitisation and Inflammatory Responses to House Dust Mite in the Lung.PMID 42154289Read ↗

Time‐dependent distinct roles of Toll‐like receptor 4 in a house dust mite‐induced asthma mouse modelSemantic proximity Read ↗

Mechanisms underlying the immune response to inhaled house dust miteSemantic proximity Read ↗

Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa.Semantic proximity Read ↗

Hemopoietic cells with features of the mast cell and basophil lineages and their potential role in allergy.Semantic proximity Read ↗

Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype.Semantic proximity Read ↗

BCR analysis of single-sorted, putative IgE <sup>+</sup> memory B cells in food allergy: <i>an ephemeral existence?</i>Semantic proximity Read ↗

Deciphering the role of platelets in severe allergy by an integrative omics approach.Semantic proximity Read ↗

Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responsesSemantic proximity Read ↗

Lung megakaryocytes display distinct transcriptional and phenotypic properties.Semantic proximity Read ↗

Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice.Semantic proximity Read ↗

Isolation of Mature (Peritoneum-Derived) Mast Cells and Immature (Bone Marrow-Derived) Mast Cell Precursors from Mice.Semantic proximity Read ↗

Interleukin-1α alters megakaryocyte maturation, promotes emperipolesis, and induces a distinct proteomic profile.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.