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Article

Interleukin-1α alters megakaryocyte maturation, promotes emperipolesis, and induces a distinct proteomic profile.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2026

Kolman Robert, Voß Hannah, Bertović Ivana, Peradinović Josip, Munitić Ivana, Engel Daniel Robert, Shevchuk Olga, Jurak Begonja Antonija

Abstract excerpt

BACKGROUND: Megakaryocytes (MKs) are large, polyploid cells and precursors of blood platelets. Interleukin (IL)-1α is a proinflammatory cytokine and a known mediator of emergency thrombopoiesis. However, its effect on MK maturation in vitro has not been studied in detail. OBJECTIVES: We aimed to investigate the phenotypical and molecular consequences of IL-1α-based MK maturation. METHODS: Murine bone marrows were...

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PMID: 40973016
DOI: 10.1016/j.jtha.2025.08.037

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